Researchers have successfully tested a technique that uses melanin-coated nanoparticles to protect bone marrow from damage commonly sustained during radiotherapy.
One of the major downsides of radiation therapy, which is commonly used to shrink cancerous tumors, is its harmful effect on normal cells. Now, thanks to research done by scientists at the Albert Einstein College of Medicine of Yeshiva University, doctors may someday use melanin-covered nanoparticles to administer higher doses of radiation to cancerous cells without compromising the healthy ones. Ekaterina Dadachova, Ph.D., and her colleagues at the university recently tested the particles in mice, which responded well to the technique after exposure to radiation.
Symptoms of bone marrow damage include a drop in the number of white blood cells and platelets. Melanin, a pigment responsible for skin color, not only curbs the formation of free radicals, which damage DNA, but it eliminates the ones that manage to form anyway. To create melanin particles tiny enough to squeeze through the liver, lungs, and spleen, Dr. Dadachova and her team layered several coats of synthesized melanin on silica (sand) particles. The particles, once injected into mice, clung onto bone marrow, as the researchers intended.
After experimenting on groups of mice subjected to various doses of particles and radiation, Dr. Dadachova and her team found that those who received melanin prior to radiation experienced less symptoms of bone marrow damage. Even better, mice who were injected with the melanin nanoparticles recovered their white blood cells and platelets much faster than the other mice did.
Dr. Dadachova and her colleagues observed no side effects to the treatment. Although some nanoparticles could be found in the bone marrow 24 hours after their injection, she maintained that phagocytic cells would remove them before they could inflict any damage.
Clinical trials testing the melanized particles on cancer patients may begin two or three years. Dr. Dadachova also surmises that the technique has potential for protecting astronauts against radiation exposure.
LONDON (AFP) – Aliens may exist but mankind should avoid contact with them as the consequences could be devastating, British scientist Stephen Hawking warned Sunday.
"If aliens visit us, the outcome would be much as when Columbus landed in America, which didn't turn out well for the Native Americans," said the astrophysicist in a new television series, according to British media reports.
The programmes depict an imagined universe featuring alien life forms in huge spaceships on the hunt for resources after draining their own planet dry.
"Such advanced aliens would perhaps become nomads, looking to conquer and colonise whatever planets they can reach," warned Hawking.
The doomsday scenario is suggested in the series "Into the Universe with Stephen Hawking" on the Discovery Channel, which began airing in the United States on Sunday.
On the probability of alien life existing, he says: "To my mathematical brain, the numbers alone make thinking about aliens perfectly rational.
"The real challenge is to work out what aliens might actually be like."
Glowing squid-like creatures, herds of herbivores that can hang onto a cliff face and bright yellow predators that kill their prey with stinging tails are among the creatures that stalk the scientist's fantastical cosmos.
Mankind has already made a number of attempts to contact extraterrestrial civilizations.
In 2008, American space agency NASA beamed the Beatles song "Across the Universe" into deep space to send a message of peace to any alien that happens to be in the region of Polaris -- also known as the North Star -- in 2439.
But the history of humanity's efforts to contact aliens stretches back some years.
The US probes Pioneer 10 and 11 were launched in 1972 and 1973 bearing plaques of a naked man and woman and symbols seeking to convey the positions of the Earth and the Sun.
Voyager 1 and 2, launched in 1977, each carry a gold-plated copper phonogram disk with recordings of sounds and images on Earth.
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A would-be saboteur arrested today at the Large Hadron Collider in Switzerland made the bizarre claim that he was from the future. Eloi Cole, a strangely dressed young man, said that he had travelled back in time to prevent the LHC from destroying the world.
The LHC successfully collided particles at record force earlier this week, a milestone Mr Cole was attempting to disrupt by stopping supplies of Mountain Dew to the experiment's vending machines. He also claimed responsibility for the infamous baguette sabotage in November last year.
Mr Cole was seized by Swiss police after CERN security guards spotted him rooting around in bins. He explained that he was looking for fuel for his 'time machine power unit', a device that resembled a kitchen blender.
Police said Mr Cole, who was wearing a bow tie and rather too much tweed for his age, would not reveal his country of origin. "Countries do not exist where I am from. The discovery of the Higgs boson led to limitless power, the elimination of poverty and Kit-Kats for everyone. It is a communist chocolate hellhole and I'm here to stop it ever happening."
This isn't the first time time-travel has been blamed for mishaps at the LHC. Last year, the Japanese physicist Masao Ninomiya and Danish string-theory pioneer Holger Bech Nielsen put forward the hypothesis that the Higgs boson was so "abhorrent" that it somehow caused a ripple in time that prevented its own discovery.
Professor Brian Cox, a former CERN physicist and full-time rock'n'roll TV scientist, was sympathetic to Mr Cole. "Bless him, he sounds harmless enough. At least he didn't mention bloody black holes."
Mr Cole was taken to a secure mental health facility in Geneva but later disappeared from his cell. Police are baffled, but not that bothered.
WASHINGTON – The FBI is warning police across the country that an anti-government group's call to remove governors from office could provoke violence. The group called the Guardians of the free Republics wants to "restore America" by peacefully dismantling parts of the government, according to its Web site. It sent letters to governors demanding they leave office or be removed.
Investigators do not see threats of violence in the group's message, but fear the broad call for removal of top state officials could lead others to act out violently. At least two states beefed up security in response.
Minnesota Gov. Tim Pawlenty said he received one of the letters but wasn't overly alarmed.
"We get all kinds of shall we say, 'interesting' mail, so it's not out of the norm," Pawlenty said Friday. "It got more attention because it went to so many governors."
As of Wednesday, more than 30 governors had received letters saying if they don't leave office within three days they will be removed, according to an internal intelligence note by the FBI and the Department of Homeland Security. The note was obtained by The Associated Press.
The FBI expects all 50 governors will eventually receive such letters.
Governors whose offices reported getting the letters included Jennifer Granholm of Michigan, Bobby Jindal of Louisiana, Chet Culver of Iowa, Dave Heineman of Nebraska, Jim Gibbons of Nevada, Brad Henry of Oklahoma, Mike Rounds of South Dakota, Bob McDonnell of Virginia, and Gary Herbert of Utah, where officials stepped up security in response to the letter.
In Nevada, screening machines for visitors and packages were added to the main entrance to the state Capitol as a precaution.
"We're not really overly concerned, but at the same time we don't want to sit back and do nothing and regret it," Deputy Chief of Staff Lynn Hettrick said.
Granholm spokeswoman Liz Boyd said federal authorities had alerted the governor that such a letter might be coming, and it arrived Monday or Tuesday. Boyd, who described the letter as "non-threatening," said it was opened by a staffer and immediately turned over to the Michigan State Police.
Jindal's office confirmed that the governor had received one of the letters and directed questions to the Louisiana State Police.
"They called us as they do for any letter that's out of the norm," said Lt. Doug Cain, a state police spokesman. He declined to provide specifics about the letter, but said, "not knowing the group and the information contained in the letter warranted state police to review it."
The FBI warning comes at a time of heightened attention to far-right extremist groups after the arrest of nine Christian militia members last weekend accused of plotting violence.
In explaining the letters sent to the governors, the intelligence note says officials have no specific knowledge of plans to use violence, but they caution police to be aware in case other individuals interpret the letters "as a justification for violence or other criminal actions."
The FBI associated the letter with "sovereign citizens," most of whom believe they are free from all duties of a U.S. citizen, like paying taxes or needing a government license to drive. A small number of these people are armed and resort to violence, according to the intelligence report.
Last weekend, the FBI conducted raids on suspected members of a Christian militia in the Midwest that was allegedly planning to kill police officers. In the past year, federal agents have seen an increase in "chatter" from an array of domestic extremist groups, which can include radical self-styled militias, white separatists or extreme civil libertarians and sovereign citizens.
CAPE CANAVERAL, Fla. – Space is about to have a female population explosion.
One woman already is circling Earth in a Russian capsule, bound for the International Space Station. Early Monday morning, NASA will attempt to launch three more women to the orbiting outpost — along with four men — aboard shuttle Discovery.
It will be the most women in space at the same time.
Men still will outnumber the women by more than 2-to-1 aboard the shuttle and station, but that won't take away from the remarkable achievement, coming 27 years after America's first female astronaut, Sally Ride, rocketed into space.
A former schoolteacher is among the four female astronauts about to make history, as well as a chemist who once worked as an electrician, and two aerospace engineers. Three are American; one is Japanese.
But it makes no difference to educator-astronaut Dorothy Metcalf-Lindenburger's 3-year-old daughter Cambria.
"To her, flying is cool. Running around is being cool. Just learning and growing up as a kid is cool. There aren't a lot of distinctions, and that's how I want it to be," said Metcalf-Lindenburger, 34, who used to teach high school science in Vancouver, Wash.
Indeed, the head of NASA's space operations was unaware of the imminent women-in-space record until a reporter brought it up last week. Three women have flown together in space before, but only a few times.
"Maybe that's a credit to the system, right? That I don't think of it as male or female," said space operations chief Bill Gerstenmaier. "I just think of it as a talented group of people going to do their job in space."
Discovery's crew of seven will spend 13 days in space, hauling up big spare parts, experiments and other supplies to the nearly completed space station. It's one of four shuttle flights remaining. Monday's liftoff time is 6:21 a.m.
Metcalf-Lindenburger and Japanese astronaut Naoko Yamazaki, both rookies, will become the 53rd and 54th women to fly in space — and the 516th and 517th spacefarers, overall. Soviet cosmonaut Yuri Gagarin became the world's first space traveler in 1961. The Soviet Union followed with the world's first spacewoman in 1963: Valentina Tereshkova.
"I'd love to have those numbers be higher," said astronaut Stephanie Wilson, 43, who will be making her third shuttle flight. "But I think that we have made a great start and have paved the way with women now being able to perform the same duties as men in spaceflight."
Wilson became the second black woman in space in 2006; one other has since followed her.
Yamazaki will become the second Japanese woman to fly in space. Dr. Chiaki Mukai was the first in 1994.
Perhaps even more astounding, at least in Japan, Yamazaki's husband quit his space station flight controller's job to follow her career and help care for their 7-year-old daughter.
"It is very rare. In Japan, it's general for men to work and for women to stay at home," Yamazaki, 39, said. Just as she was inspired by Mukai, "hopefully, I can inspire younger women as well."
Rounding out the foursome will be Tracy Caldwell Dyson, who was launched aboard a Soyuz rocket from Kazakhstan on Friday with two Russian men. They will arrive Sunday and settle in for a six-month stay.
Caldwell Dyson, 40, who has a doctorate in chemistry, grew up in Southern California assisting her electrician father. She wasn't sure what to do with her life until she learned that a schoolteacher was reaching for the stars. Christa McAuliffe died trying; she was killed along with six others aboard Challenger in 1986.
McAuliffe, a high school teacher, also inspired Metcalf-Lindenburger, who was 14 years old when she attended Space Camp in Huntsville, Ala., several years after the Challenger launch accident.
Now it's Metcalf-Lindenburger's turn to ride a rocket.
"Of course, the shuttle has its risks. But we've tried to make it as safe as possible, and there are so many things that we gain from it and there are so many reasons to fly it," she said.
Metcalf-Lindenburger was a young earth-science and astronomy teacher when she stumbled onto NASA's want ad for astronaut-educator in 2003. A student had asked how astronauts go to the bathroom in space, and an embarrassed Metcalf-Lindenburger promised to look up the answer.
Today she's no longer fazed by toilet questions.
"My daughter is just potty training, and now I talk about it on a daily basis," she said with a chuckle.
PORT-AU-PRINCE (Reuters) – Dressed in white, shaking decorated gourd rattles and singing praises to "Olorum Papa" (God the Father), several hundred practitioners of Haiti's voodoo religion held a public ceremony on Sunday to honor those killed in the January 12 earthquake.
While several Christian ceremonies have been held to mourn the hundreds of thousands of quake dead, this was the first national commemoration by Haiti's voodoo religion, which has had to defend itself against accusations by some Evangelical preachers that it somehow caused the deadly natural disaster.
The supreme head of Haiti's voodoo religion, Max Beauvoir -- an elderly, bespectacled man dressed in an embroidered white robe and bonnet -- presided over the ceremony in a central Port-au-Prince square. It coincided with the Catholic feast day of Palm Sunday, the start of Easter Holy Week.
More than half of Haiti's nearly 10 million people are believed to practice voodoo, a religion brought from West Africa several centuries ago by slaves forced to work on the plantations of their white masters in what was then the rich French Caribbean colony of Saint Domingue. The religion is recognized by Haiti's state and protected by the constitution.
"Olorum Papa, hear our cry to you," chanted the worshipers. The women wore white robes, some trimmed with lace and embroidery, and black headscarves; the men white shirts and trousers, some with black hats.
To the sound of rattles and drums, the celebrants held a Booroum, a voodoo ritual which they believe sends the souls of the dead "under water" so they can be cleansed and return to life as better beings.
"Hounkou Bolokou Djavohoun Bohoun", chorused the worshipers, repeating an ancient voodoo incantation intended to encourage the souls of the dead.
"The people who died did not die, they went to another world, to live, under water," Beauvoir, who was educated at City College of New York and the Sorbonne in Paris, told the crowd from a stage, surrounded by other "houngan" or voodooo priests.
VOODOO 'GIVES US FREEDOM'
"Ai Bobo (Amen)," shouted the celebrants, some of whom also wore black armbands. Some greeted each other with an elaborate salutation between voodoo adherents that involves a complex handshake and embrace.
"It's voodoo that gives us freedom," one houngan, Jean Claude Bazile, told Reuters, recalling that it had survived as a living religion since playing an important part in Haiti's independence in 1804. It was a revolt by black slaves, many of them voodoo practitioners, that triggered the overthrow of French colonial rule.
Bazile rejected public statements made by some local Evangelical preachers since the quake, who he said had tried to discredit voodoo by telling people that the African-born religion was responsible for bringing on the earthquake.
"Voodoo is not for making evil, but good," he said.
"The other religions want to crush us, they think we're too strong," he said. "Everyone was hit by the earthquake, it was Nature," Bazile added.
After the catastrophic quake, which the government says may have killed more than 300,000 people, Beauvoir complained to President Rene Preval about the anonymous mass burials of tens of thousands of dead, which he said went against voodoo and Haitian culture.
Dumping the dead in hurriedly excavated mass graves without proper rites is seen as desecration in a country where many believe in zombies -- dead bodies brought back to life by supernatural forces who could persecute the living.
LONDON – When it comes to predicting earthquakes, toads — warts and all — may be an asset.
British researchers said Wednesday that they observed a mass exodus of toads from a breeding site in Italy five days before a major tremor struck, suggesting the amphibians may be able to sense environmental changes, imperceptible to humans, that foretell a coming quake.
Since ancient times, anecdotes and folklore have linked unusual animal behavior to cataclysmic events like earthquakes, but hard evidence has been scarce. A new study by researchers from the Open University is one of the first to document animal behavior before, during and after an earthquake.
The scientists were studying the common toad — bufo bufo — at a breeding colony in central Italy when they noticed a sharp decline in the number of animals at the site. Days later, a 6.3-magnitude earthquake hit, killing hundreds of people and badly damaging the town of L'Aquila.
Researcher Rachel Grant said the findings suggested "that toads are able to detect pre-seismic cues such as the release of gases and charged particles, and use these as a form of earthquake early warning system."
Initially puzzled by the toads' disappearance in the middle of the breeding season, the scientists tracked the population in the days that followed. They found that 96 percent of males — who vastly outnumber females at breeding spots — abandoned the site, 46 miles (74 kilometers) from the quake's epicenter, five days before it struck on April 6, 2009.
The number of toads at the site fell to zero three days before the quake, according to the study, published in the Zoological Society of London's Journal of Zoology.
"A day after the earthquake, they all started coming back," said Grant, the report's lead author. "The numbers were still lower than normal and remained low until after the last aftershock."
She said one possibility is that the animals sensed a change in the amount of radon gas emitted by the Earth because of the buildup of pressure prior to a quake.
Scientists also have surmised that animals may be able to detect minor tremors imperceptible to humans, or that they sense electrical signals emitted by rocks under stress before an earthquake.
Grant said the sense may be the result of millions of years of evolution, a trigger that tells the toads to move to safer ground.
"An earthquake could wipe out a population in that area," she said. "A landslide or flood could wipe out virtually 100 percent of the males, and quite a lot of the females."
Several countries have sought to use changes in nature — mostly animal behavior — as an early warning sign, without much success.
The city of Tokyo spent years in the 1990s researching whether catfish behavior could be used to predict earthquakes, but abandoned the study as inconclusive.
Roger Musson, a seismologist with the British Geological Survey, said the problem studies like the Italian toad research lay in proving the connection between the animal behavior and the quake.
"What happens is somebody observes some strange animal behavior then there is an earthquake, so they link the two," said Musson. "There are probably plenty of cases in which there is strange animal behavior and no earthquake."
He said the new study was "another bit of data in the large pile that has been accumulating over the years. But it's not in any shape or form a breakthrough."
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Namaste is a common spoken valediction or salutation originating from the Indian subcontinent. When spoken to another person, it is commonly accompanied by a slight bow made with hands pressed together, palms touching and fingers pointed upwards, in front of the chest. Namaste is derived from Sanskrit and term "Namas" which has many different meanings such as bow, prostration, obedience, reverential salutation, adoration. Known to many say the gesture of saying the God in me recognize or bow to the God in you.
The wise man or woman understands that religions have more in common than difference and deals with the science, esoteric, Gnostic, symbolism, personification, allegory and inner meanings to balance their mental, physical and spiritual.
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